LATS1-Beclin1 mediates a non-canonical connection between the Hippo pathway and autophagy

LATS1-Beclin1 mediates a non-canonical connection between the Hippo pathway and autophagy

Blog Article

Understanding the mechanisms of evasive resistance in cancer is of great importance to double-stitched-harness-leather-futurity-knot-brid develop efficient therapies.Analyzing the molecular mechanisms underlying therapy resistance of hepatocellular carcinoma (HCC), we have discovered a kinase-activity independent role of LATS1 (large tumor suppressor) but not LATS2 in regulating sorafenib-induced lethal autophagy in HCC.We have found that the autophagy regulatory role of LATS1 is a general phenomenon in response to various stimuli of autophagy induction which relies on a LATS1-specific protein domain.

Mechanistically, the autophagy regulatory role of LATS1 is coupled with Beclin-1 (BECN1) Zodiac Ranger Parts K27-linked ubiquitination and BECN1 self-dimerization.Our study highlights a LATS1-mediated non-classical interaction between the Hippo signaling pathway and autophagy in therapy response and carcinogenesis.